School of
Pharmacy

Pharmacy

Xiangming Zha

Xiangming Zha
Associate Professor
Pharmacy

Contact Info
xzha@umkc.edu
816-235-1615
HSB 5252
Brain acid signaling through acid-sensing ion channels and proton-sensitive GPCRs, and their role in neuron function, neuronal injury, ischemia, and cerebrovascular dysfunction.

About

Xiangming Zha joined the School of Pharmacy in August 2021, as an associate professor in the Division of Pharmacology and Pharmaceutical Sciences.  He came to UMKC from Mobile, Alabama, where was an associate professor in the Department of Physiology and Cell Biology at the University of South Alabama College of Medicine.

Dr. Zha received his Ph.D. in biology at the University of Iowa.  He earned an M.S. in neurobiology from the Shanghai Brain Research Institute, Chinese Academy of Sciences, Shanghai, China; and a B.S. in biochemical engineering from Shanghai Jiao Tong University, Shanghai, China.

Selected Publications: (ORCID: 0000-0001-9490-2731)

  1. Zha XM, Wemmie JA, Green SH, and Welsh MJ. (2006) ASIC1a is a postsynaptic proton receptor that affects the density of dendritic spines. Proc. Natl. Acad. Sci. 103: 16556-16561. 
  2. Zha XM, Wang R, Collier DM, Wemmie JA, Snyder P, and Welsh MJ. (2009) Oxidant regulated intersubunit disulfide bond formation between ASIC1a subunits. Proc. Natl. Acad. Sci. 106: 3573–3578.
  3. Zha XMCosta V, Harding A, Reznikov L, Price MP, Benson CJ, and Welsh MJ. (2009) ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci. 29: 8839-46.
  4. Jing L*, Chu XP*, Jiang YQ*, Collier DM, Wang B, Jiang Q, Snyder PM and Zha XM. (2012) N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling. J.Neurosci. 32:4080-91.
  5. Wu J, Xu Y, Jiang YQ, Xu J, Hu Y, and Zha XM. (2016) ASIC subunit ratio and differential surface trafficking in the brain. Mol. Brain 9: 4.
  6. Jiang N*, Wu J*, Leng T*, Yang T, Zhou Y, Jiang Q, Wang B, Hu Y, Ji YH, Simon RP, Chu XP, Xiong ZG#, and Zha XM#. (2017) Region specific contribution of ASIC2 to acidosis- and ischemia-induced neuronal injury. J Cereb Blood Flow Metab 37: 528-540.
  7. Xu Y*, Jiang YQ*, Li C, He M, Rusyniak WG, Annamdevula N, Ochoa J, Leavesley SJ, Xu J#, Rich TC, Lin MT, and Zha XM#. (2018) Human ASIC1a mediates stronger acid-induced responses as compared to mouse ASIC1a. FASEB J 32: 3832-3843.
  8. Xu Y, Lin MT, and Zha XM. (2020) GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior. Molecular Brain 13:132. DOI: 10.1186/s13041-020-00672-8.
  9. Wang T*, Zhou G*, He M, Xu Y, Rusyniak GW, Xu Y, Ji Y, Simon RP, Xiong ZG, and Zha XM. (2020) GPR68 is a neuroprotective proton receptor in brain ischemia. Stroke 51: 3690-700. DOI: 10.1161/STROKEAHA.120.031479
  10. Zhou G*, Wang, T*, and Zha XM. (2021) RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain. FASEB J 35: e21461. DOI: 10.1096/fj.202002511R
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