Jianping Wang, M.D., Ph.D.
UMKC School of Pharmacy
2464 Charlotte St.
Kansas City, MO 64108
Post-doctoral Associate, National Institutes of Health/Scripps Research Institute
Ph.D. in Pharmacology, Louisiana State University Medical Center (LSUMC)
M.S. in Immunology, Second Military Medical University, Shanghai, China
M.D., Second Military Medical University, Shanghai, China
The immune system and nervous system communicate with each other throughout human life. These system-crossing interactions are implicated in both brain physiology and pathophysiology. Impact of the immune system on brain appears to be mediated by protein molecules known as cytokines, which are grouped into families of interleukins, interferons, chemokines, tumor necrosis factors and transforming growth factors. As the prime innate immune mediators, interferons (IFNs) have been hypothesized to be in association with a number of neuropsychiatric disorders. To understand the roles of these pleiotropic endogenous molecules in the etiopathogenesis of clinical illnesses, we have been using integrated approaches (behavioral, histological, pharmacological, molecular and genetic ones). Laboratory animals (modeling relevant clinical conditions) and cell/tissue cultures are used to elucidate the molecular entities underlying the observed behavioral abnormalities. Our studies demonstrate that interferon is a double-edged sword. These anti-viral cytokines are not only pivotal for host defense against various infections and tissue damage, but may also act as the pathogenic factors for neurodevelopmental disorders such as depression, bipolar disorder, schizophrenia, epilepsy and autism.
Sun, L. Tian, Z., & Wang, J. (2010). A direct cross-talk between interferon-gamma and sonic hedgehog signaling that leads to the proliferation of neuronal precursor cells. Brain Behavior & Immunity. 24 (2):220-228.
Wang, J., Dunn, A.J., Roberts, A.J & Zhang, H. (2009). Decreased immobility in swimming test by homologous interferon-alpha in mice accompanied with increased cerebral tryptophan level and serotonin turnover. Neurosci. Lett. 452(2):96-100.
Wang, J., Campbell, I.L. & Zhang, H. (2008). Systemic interferon-alpha directly regulates interferon-stimulated genes in the central nervous system. Molecular Psychiatry. 13:293-301.
Lin, W., Kemper, A., McCarthy, K.D., Pytel, P., Wang, J.P., Campbell, I.L., Utset, M.F., Popko, B. (2004). Interferon-gamma Induced medulloblastoma in the developing cerebellum. J. Neurosci. 24:10074-10083.
Wang, J., Pham-Mitchell, N., Schindler, C. and Campbell, I.L. (2003). Dysregulated sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain. J. Clin. Invest. 112:535-543.
Wang, J., Schreiber, R.D. and Campbell, I.L. (2002). STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the CNS. Proc. Natl. Acad. Sci. USA. 99:16209-16214.
Wang, J. and Dunn, A. J. (1999). The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis induced by endotoxin and interleukin-1beta. Brain Res. 815:337-348.
Wang, J. and Dunn, A. J. (1998). Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism. Neurochem. Internl. 33:143-154.
Chronic Interferon-alpha Activity & Body Weigh Regulation. Faculty Research Incentive Grant (UMKC, School of Pharmacy, Division of Pharmacology & Toxicology). Total Cost: $15,000. 12/01/14 – 11/30/15.
Interferon-gamma, Neuroimmune Crosstalk & CNS Impacts. Research Bridge Fund (UMKC, School of Pharmacy). Total Cost: $15,000. 10/01/12 – 09/30/13.
Alcohol Treatment, Sonic Hedgehog & Granule Neuron Precursor Proliferation. University of Missouri Research Board (UMRB). Total cost: $63,000. 09/01/11 – 08/31/13.
Interferon-alpha & Neurobehavioral Deficits. National Institutes of Health (MH 069524). Total Cost: $493,142. 08/13/04 – 011/31/07.