Orisa J. Igwe, Ph.D., R.Ph.


UMKC School of Pharmacy
2464 Charlotte Street
HSB 2247
Kansas City, MO 64108

Phone: 816-235-1996
Email: igweo@umkc.edu

Igwe_Orisa web


My undergraduate training was in pharmacy with a B.S. degree, graduating with the Latin honor of summa cum laude from the College of University of Louisiana at Monroe. I am a registered pharmacist in Louisiana, Ohio and Minnesota, although my licensure is not currently maintained in any of these states. I obtained a M.S. degree in toxicology from the University of Kentucky, Lexington, and earned a Ph.D. in environmental health with a specialty in inhalation toxicology and industrial hygiene from the University of Cincinnati, Ohio, in 1985. I had a year of postdoctoral training in molecular biology at the Eppley Cancer Research Institute, Omaha and a further training in molecular and behavioral neuroscience under Professor Alice A. Larson at the University of Minnesota, St. Paul (1986 -1990). I have been at the UMKC School of Pharmacy since 1991. I have been a member of the graduate and regular doctoral faculty since 1995, and have served as thesis and dissertation director for M.S and Interdisciplinary Ph.D. (IPh.D.) students in the division. Furthermore, I have served in the thesis and dissertation committees of several M.S and IPh.D. students.

I serve as a reviewer for many scientific journals, and ad hoc on NIH Special Emphasis Panel/Scientific Review Group 2009/10 ZRG1 IFCN-A (58) R.

My research interests have focused on:
(i) Understanding the fundamental mechanisms that underlie the hyperalgesic or allodynic states, which characterize chronic inflammatory or neuropathic pain states.
(ii) Defining the role of phospholipids/Ca2+ pathways in neuronal transmission deficits associated with aging.
Over the years, my research interests have been funded by NIH, The National Headache Foundation and University of Missouri Research Board (UMRB) (1998 and 2004).

Recent grants:
UMRB November 2004 for $48,983

Recent publications:
(i) Igwe OJ (2006) Agents that act by different mechanisms modulate the activity of protein kinase C βII isozyme in the spinal cord during peripheral inflammation. Neuroscience 138 (1): 313 – 328.
(ii) Igwe OJ (2005) Modulation of peripheral inflammation in sensory ganglia by nuclear factor κB decoy oligodeoxynucleotide: Involvement of Src kinase pathway. Neurosci. Lett. 381: 114 – 119.
(iii) Moolwaney AS, Igwe OJ (2005) Regulation of the cyclooxygenase-2 system by interleukin 1ß through mitogen-activated protein kinase signaling pathways: A comparative study of human neuroglioma and neuroblastoma cells. Mol. Brain Res. 137 (1-2): 202-212.
(iv) Igwe OJ, Filla MB (1997) Aging-related regulation of myo-inositol 1,4,5-trisphosphate signal transduction pathway in the rat striatum. Brain Res Mol Brain Res. 46(1-2): 39-53.