Hari K. Bhat
Hari K. Bhat, Ph.D.
Division of Pharmacology and Toxicology
UMKC Health Sciences Building
2464 Charlotte St.
Kansas City, MO 64108
Dr. Bhat received his B.Sc. in Biology and Chemistry, and M.Sc. in Organic Chemistry from University of Kashmir, Kashmir, India. He received his Ph.D. in Biochemistry from the University of Texas Medical Branch, Galveston, Texas.
Dr. Bhat's research interests focus on the elucidation of biochemical and molecular mechanisms of a) hormonal breast carcinogenesis; b) breast cancer chemoprevention using phytoestrogens; c) endocrine disruptors; and d) unequal burden of breast cancer among minority population. The mechanisms of hormonal breast carcinogenesis are being investigated using animal models, relevant cell lines and human tissue samples.
- 2007 - Editorial Board Member, Journal of Biochemical and Molecular Toxicology
- 2006 - Editorial Board Member, Journal of Medical Hypothesis and Research
- Mense, S.M., Singh, B., Remotti, F., and Bhat, H.K. (2009) Vitamin C and Î±-Naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female ACI rats. Carcinogenesis (in press).
- Adibi, J.J. Hauser, R., Williams, P.L., Whyatt, R.M., Thaker, H.M., Nelson, H., Herrick, R., and Bhat, H.K. (2009) Placental biomarkers of phthalate effects on mRNA transcription: application in epidemiologic research. Env. Health (in press)
- Whyatt, R.M, Adibi, J.J., Calafat, A.M., Camann, D.E., Rauh, V., Bhat, H.K., Perera, F.P., Andrews, H., Just, A.C., Hoepner, L., Tang, D. and Hauser, R. (2009). Prenatal di (2-ethylhexyl) phthalate exposure in relation to length of gestation among a cohort of inner-city mothers and their newborn. Pediatrics (in press)
- Singh, B., Mense, S.M., Remotti, F. and Bhat, H.K. (2009) Inhibition of estrogen-induced breast carcinogenesis by butylated hydroxyanisol. J. Biochem. Mol. Toxicol. (in press)
- Mense, S.M., Remotti, F., Bhan, A., El-Tamer, M., Singh, B., and Bhat, H.K. (2008) Estrogen-Induced Breast Cancer: Alterations in Breast Morphology and Oxidative Stress as a Function of Estrogen Exposure. Toxicol Appl. Pharmacol., 232, 78-85.
- Mense, S.M., Chabbra, J. and Bhat, H.K. (2008) Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin. J. Steroid Biochem. Mol. Biol., 110, 157-162.
- Desai, A. G., Qazi, G.N., Ganju, R.K., El-Tamer, M., Singh, J., Saxena, A.K., Bedi, Y.S. and Bhat. H.K. (2008) Medicinal Plants and Cancer Chemoprevention. Curr. Drug Metabol., 9, 581-591.
- Mense S.M., Ganju, R.K. and Bhat, H.K. (2008) Phytoestrogens and breast cancer prevention: Possible mechanisms of action. Environ. Health Perspect., 116, 426-433.
- Adibi, J.J., Whyatt, R.M., Williams, P., Nelson, H., Herrick, R., Bhat, H.K., Calafat, A.M., Silva, M.J., Camann, D., Perera, F.P., and Hauser, R (2008) Characterization of phthalate exposure assessed by repeat air and urine samples among pregnant women. Environ. Health Perspect., 116, 467-473.
- Paruchuri, V., Prasad, A., McHugh, K., Polyak, K., Bhat, H.K. and Ganju, R.K. (2008) S100A7-Downregulation Inhibits Epidermal Growth Factor-Induced Signaling in Breast Cancer Cells and Blocks Osteoclast Formation. PLoS ONE, 5, e1741.
- Molecular mechanisms and importance of oxidative stress in estrogen-induced carcinogenesis; 1R01-CA109551-01; 07/01/2006 - 6/30/2010; NIH/NCI $290,000 /year