Ashim K. Mitra

 

Ashim K. Mitra, Ph.D.

Chairman, Pharmaceutical Sciences

University of Missouri-Kansas City School of Pharmacy
Division of Pharmaceutical Sciences
HSB 5258
2464 Charlotte St.
Kansas City, MO 64108
Phone: 816-235-1615
Fax: 816-235-5779
E-mail: mitraa@umkc.edu

Biography

Dr. Mitra received his Ph.D. in Pharmaceutical Chemistry in 1983 from the University of Kansas. Upon graduation he was employed as an Assistant Professor of Biopharmaceutics at the University of Nebraska Medical Center for one year. In 1984, he joined Purdue University as an Assistant Professor and later became an Associate Professor of Physical Pharmacy from 1989-1994. That year in 1994, he was accepted as Professor and Chairman of UMKC School of Pharmacy, Division of Pharmaceutical Sciences. He received the University of Missouri Curators' Professor of Pharmacy Award in 2002. Within two years, he was appointed Co-Director, Kansas City Vision Research Center, UMKC School of Medicine and UMKC Vice Provost for Interdisciplinary Research.

» Research Interests
» Awards and Honors
» Recognition
» Patents
» Current Funding
» Recent Publications
» Recent Books
» Recent Book Chapters

 


 

Research Interests

His current research interests are focused on two main areas: delivery and targeting of antiviral agents and development of noninvasive delivery systems for peptide and protein drugs.

» Curriculum Vitae

Recent Awards and Honors:

2013 - University of Missouri's Patent, Copyright, and University-Sponsored Educational Materials Committee, University of Missouri System

2011 - Chairman, USP Council of Experts, General Chapter <771> Ophthalmic Preparations Expert Panel. U.S. Pharmacopeia, Rockville, MD

Recognitions Around The World
April 2013

"Approaches for enhancing oral bioavailability of peptides and proteins", Jwala Renukuntla, Aswani Dutt Vadlapudi, Ashaben Patel, Sai H.S. Boddu and Ashim K. Mitra. (April 2013) International Journal of Pharmaceutics was recognized as one of the most downloaded article from ScienceDirect in the last 90 days.
Link to publication

March 2013

"Novel Strategies for Anterior Segment Ocular Drug Delivery" Authors: Kishore Cholkar, Sulabh P. Patel, Aswani Dutt Vadlapudi, Ashim K. Mitra, Journal of Ocular Pharmacology and Therapeutics. March 2013: 106-123. This publication has been one of the most read articles.
Link to publication

January 2013

Mitochondrial localization of P-glylcoprotein and peptide transporters in corneal epithelial cells - Novel stragegies for intracellular drug targeting, Megha Barot | Mitan R. Gokulgandhi | Dhananjay Pal | Ashim K. Mitra, (January 2013), Experimental Eye Research, recognized this article was rated most-downloaded articles in last 90 days.
Link to publication

November 2011, February, 2012, June 2012

"Ocular Drug Delivery" Authors: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, and Ashim K. Mitra; AAPS J. 2010 Sep;12(3):348-60. This publication once again became one of the "Top 5" downloaded articles (within 90 days) in the AAPS Journal and can be accessed via The AAPS Journal on www.Springer.com. (80 Citations)

April 2010

Ranked #3rd Author in the World in the Prodrug Arena. Click here for more informaiton.

May 2009

Recent perspectives in ocular drug delivery. Authors: Ripal Gaudana, Jwala Jwala, Sai HS Boddu, Ashim K Mitra. Pharm Res. 2009 May;26(5):1197-216. This publication has been one of the most downloaded articles from Pharmaceutical Research and currently has more than 125 citations.

Ranked #5th on the list of "Top Ten Researchers" in the world by Pharmaceutical Research - official Journal of America Association of Pharmaceutical Scientist (AAPS). More information here.

Patents

United States Patent and Trademark Office
US Patent Inventors: Ashim K. Mitra, Poonam R. Velagaleti, Subramanian Natesan
US Continuation Patent Application of Mitra et al.
Serial No.: US 13/974,241
Filed: August 23, 2013
Patent Title: "Ophthalmic Compositions"
Our Ref. No.: 095691-010412/CON2

Unites States Patent and Trademark Office
US Patent Application Publication: # US 2011/0250283 A1
Authors: Ashim K. Mitra, Gyan Prakash Mishra
Pub Date: October 13, 2011
Patent Title: "Pentablock Polymers"

Unites States Patent and Trademark Office
US Patent Issued: # US 7,951,774, B2
Authors: Ashim K. Mitra, Swapan K. Samanta, Ravi S. Talluri
Patent Issued Date: May 31, 2011
Patent Title: "Stereochemically Defined Dipeptide Esters of Antiviral Agents for Enhanced Ocular Treatment"

United States Patent and Trademark Office
US Patent Issued: # US 2011/0105417 A1
Authors: Ashim K. Mitra, Swapan Kumar Samanta
Patent Issue Date: May 5, 2011
Patent Title: Drug Conjugates

United States Patent and Trademark Office
US Patent Issued: # US 7,910,553 B2
Authors: Ashim K. Mitra, Soumyajit Majumdar, Ritesh Jain, and Yasser Nashed
Patent Issue Date: March 22, 2011
Patent Title: "Peptidyl Prodrugs That Resist P-Glycoprotein Mediated Drug Efflux"

United States Patent and Trademark Office
US Patent Issued: # US 2009/0092665 A1
Authors: Ashim K. Mitra, Poonam R. Velagaleti, Subramanian Natesan
Patent Issue Date: April 9, 2009
Patent Title: "Ophthalmic Compositions Comprising Calcineurin Inhibitors or Mtor Inhibitors"

United States Patent and Trademark Office
US Patent Issued: # US 7,553,812 B2
Authors: Ashim K. Mitra
Patent Issue Date: June 30, 2009
Patent Title: "Acyclovir-Peptide Analogs"

United States Patent and Trademark Office
US Patent Issued: # US 7,825,086, B2
Author: Ashim K. Mitra
Patent Issue Date: November 2, 2010
Patent Title: "Acyclovir-Peptide Analogs"

United States Patent and Trademark Office
US Patent Issued: # US 2010/0310642 A1
Authors: Ashim K. Mitra, Poonam R. Velagaleti, and Ulrich M. Grau
Patent Issue Date: December 9, 2010
Patent Title: "Topical Drug Delivery Systems for Ophthalmic Use"

Current Funding

1. Co-Investigator, (Summa Health System) 1 R01 EY020916-01A1, "Suppression of Ocular Scarring-Controlled Delivery of an ALK-5 Inhibitor", $186,000, 09/01/2011-08/31/2014.
2. Principal Investigator, 1 R01 AI071199-01-A2 "Protease Inhibitor Analogues for Enhanced Transport Across Blood-Brain Interfaces", $1,862,500, 04/01/2007-12/31/2013.

Recent Publications (Selected from over 300):

1. Vadlapudi AD, Mitra AK., Sustained Delivery of Biologics to Back of the Eye, Journal of Biotechnology and Biomaterials, August 2013 [IN PRESS].
2. Mitra AK. Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells [Int. J. Pharm. 443 (2013) 245-253], (Reply to Letter to the Editor), Int J Pharm. 2013. [Epub ahead of print] [IN PRESS].
3. Barot M, Gokulgandhi MR, Agrahari V, Pal D, Mitra AK, Monocarboxylate transporter mediated uptake of moxifloxacin on human retinal pigmented epithelium cells, Journal of Pharmacy and Pharmacology, 2013 [IN PRESS].
4. Vadlapatla RK, Vadlapudi AD, Pal D, Mitra AK., Mechanisms of Drug Resistance in Cancer Chemotherapy: Coordinated Role and Regulation of Efflux Transporters and Metabolizing Enzymes, Curr Pharm Des. 2013, June 24. [IN PRESS].
5. Vadlapatla RK, Vadlapudi AD, Ponnaluri VK, Pal D, Mukherji M, Mitra AK., Molecular Expression and Functional Activity of Efflux and Influx Transporters in Hypoxia Induced Retinal Pigment Epithelial Cells, Int J Pharm. 2013, June 24. [IN PRESS].
6. Vadlapatla RK, Vadlapudi AD, Mitra AK. Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular Diseases. Curr Drug Targets 2013. [IN PRESS].
7. Patel M, Mandava NK, Vadlapatla RK, Mitra AK., Recent patents and emerging therapeutics for HIV infections: A focus on pprotease inhibitors, Pharmaceu Patent Analyst 2013 [IN PRESS].
8. Kwatra D, Mitra AK., Drug Delivery in Ocular Diseases: Barriers and Strategies, World J of Pharmacol 2013 [IN PRESS].
9. Vadlapudi AD, Vadlapatla RK, Earla R, Sirimulla S, Bailey JB, Pal D, Mitra AK, Novel Biotinylated Lipid Prodrugs of Acyclovir for the Treatment of Herpetic Keratitis (HK): Transporter Recognition, Tissue Stability and Antiviral Activity, Pharma Res, 2013 [IN PRESS].
10. Patel A, Cholkar K, Agrahari V, Mitra AK, "An Overview Of Ocular Drug Delivery Systems", World J of Pharmacol, 4/4/2013 [IN PRESS].
11. Wang Z, Luo S; Sheng Y, Samanta S, Pal D, Mitra AK. Stereoisomeric peptide prodrug modification to inprove intestinal absorption of saquinavir: Synthesis and in vitro evaluation, Intl J. Phar & Eng (IJPE) ISSN 1(2):93-112, 2013.
12. Barot M, Gokulgandhi M, Patel S, Mitra AK., Microvascular Complications and Diabetic Retinopathy: Recent Advances and Future Implications. Future Medicinal Chemistry, (March) 5(3):301-314, 2013
13. Renukuntla J, Vadlapudi AD, Patel A, Boddu SHS, Mitra AK. Approaches for Enhancing Oral Bioavailability of Peptides and Proteins, Int J Pharm, (Feb) 447(1-2):75-93, 2013.
14. Kwatra D, Subramaniam D, Ramamoorthy P, Standing D, Moran E, Velayutham R, Mitra AK, Umar S, and Anant S, Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy, Evidence-Based Complementary and Alternative Medicine, Jan (Article ID) 702869, pg 14, 2013.
15. Patel M; Dalvi P; Gokulgandhi MR; Kesh S; Kohli T; Pal D; Mitra AK. Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells, Int J Pharm (Feb) 443(1-2):245-253, 2013.
16. Cholkar K, Patel SP, Vadlapudi AD, Mitra AK., Novel strategies for anterior segment ocular drug delivery, J Ocular Pharmacol & Therapeu, (Mar) 9(2):106-123, 2013.
17. Gaudana R; Gokulgandhi M; Varun K; Deep D; Mitra AK. Design and evaluation of a novel nanoparticulate based formulation encapsulating a HIP complex of lysozyme, Pharmaceutical Development and Technology, (May) 18(3):752-759. 2013.
18. Vadlapudi AD and Mitra AK. Nanomicelles: An Emerging Platform for Drug Delivery to the Eye. Therapeutic Delivery, (Jan) 4(1):1-3, 2013.
19. Vadlapudi AD, Vadlapatla RK, Mitra AK, Update On Emerging Antivirals For The Management Of Herpes Simplex Virus Infections: A Patenting Perspective, Recent Pat Antiinfect Drug Discov. (April) 8(1):55-67, 2013.
20. Wang Z, Pal D, Patel A, Kwatra D, Mitra AK., Influence of overexpression of efflux proteins on the function and gene expression of endogenous peptide transporters in MDR-transfected MDCKII cell lines. Int J Pharm. (Jan) 441(1-2):40-49, 2013.
21. Vadlapudi AD, Vadlapatla RK, Pal D, Mitra AK. Biotin Uptake by T47D Breast Cancer Cells: Functional and Molecular Evidence of Sodium-Dependent Multivitamin Transporter (SMVT), Int J Pharm. (Jan) 441(1-2):535-543, 2013.
22. Barot M; Gokulgandhi MR; Pal D; Mitra AK, Mitochondrial localization of P-glycoprotein and peptide transporters in corneal epithelial cells -Novel strategies for intracellular drug targeting, Exp Eye Res. (Jan) 106:47-54, 2013.
23. Tamboli V, Mishra GP, Mitra AK., Novel pentablock copolymer (PLA-PCL-PEG-PCL-PLA) based nanoparticles for controlled drug delivery: Effect of copolymer compositions on the crystallinity of copolymers and in vitro drug release profile from nanoparticles, Colloid Polym Sci., pg 1-11, Nov 2012.
24. Vadlapudi AD, Vadlapatla RK, Pal D, and Mitra AK, Functional and Molecular Aspects of Biotin Uptake via SMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells, The AAPS Journal, (Dec) 14(4):832-842, 2012.
25. Gokulgandhi MR, Vadlapudi AD, Mitra AK, Ocular Toxicity from Systemically Administered Xenobiotics, Expert Opin Drug Metab Toxicol. (Oct) 10:1277-12791, 2012.
26. Minocha M, Khurana V, Mitra AK, Determination of pazopanib (GW-786034) in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry (LC/MS-MS), Journal of Chromatography B, (Jul) 901:85-92, 2012.
27. Patel M, Vadlapatla RK, Pal D, Mitra AK. Molecular and functional characterization of riboflavin specific transport system in rat brain capillary endothelial cells. Brain Research, (Aug) 1468:1-10, 2012.
28. Earla R, Cholkar K, Gunda S, Earla RL, Mitra AK, Bioanalytical method validation of rapamycin in ocular matrix by QTRAP LC-MS/MS: application to rabbit anterior tissue distribution by topical administration of rapamycin nanomicellar formulation, Journal of Chromatography-B, 908, 76-86, 2012.
29. Kwatra D, Budda B, Vadlapudi AD, Vadlapatla RK, Pal D, Mitra AK, Transfected MDCK cell line with enhanced expression of CYP3A4 and P-Glycoprotein as a model to study their role in drug transport and metabolism. Mol Pharm. (Jun) 9(7):1877-1886, 2012.
30. Patel M, Vadlapatla RK, Shah S, Mitra AK. Molecular expression and functional activity of sodium dependent multivitamin transporter in human prostate cancer cells. Int J Pharm. (Oct) 436(1-2):324-331, 2012.
31. Minocha M, Khurana V, Qin B, Pal D, Mitra AK, Co-administration strategy to enhance brain accumulation of vandetanib by modulating P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) mediated efflux with m-TOR inhibitors, Int J Pharm., 434:306-314, 2012.
32. Vadlapudi AD, Vadlapatla RK, Kwatra D, Earla R, Samanta SK, Pal D, Mitra AK, Targeted Lipid Based Drug Conjugates: A Novel Strategy for Drug Delivery, Int J Pharm. 434, 315-324, 2012.
33. Minocha M, Khurana V, Qin B, Pal D, Mitra AK, Enhanced brain accumulation of pazopanib by modulating P-gp and Bcrp1 mediated efflux with canertinib or erlotinib, Int J Pharm. 436(1-2); 127-134, 2012.
34. Vavilala DT, Ponnaluri VKC, Vadlapatla RK, Pal D, Mitra AK, Mukherji M, Honokiol inhibits HIF pathway and hypoxia induced expression of Histone Lysine demethylases, Int J Pharm., Biochemical and Biophysical Res Communications. 422:369-374, 2012.
35. Wang Z, Pal D, Mitra AK, Stereoselective Evasion of P-glycoprotein, CYP3A and Hydrolases by Peptide Prodrug Modification of Saquinavir, J Pharm Sci. 101(9):3199-3213, 2012.
36. Barot M, Bagui M, Gokulgandhi MR, Mitra AK, Prodrug Strategies in Ocular Drug Delivery, Med Chem. (Jul) 8(4):753-768,2012.
37. Gaudana RJ, Gokulgandhi MR, Boddu SHS, Mitra AK, "Recent Overview of Ocular Patents", Recent Pat Drug Deliv Formul. (Aug) 6(2):95-106, 2012.
38. Ande A, Earla R, Jin M, Silverstein PS, Mitra AK, Kumar A, Kumar S., An LC-MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes, Drug Alcohol Depend. (Sept) 125(1-2):49-59, 2012.
39. Gokulgandhi MR, Barot M, Baguim M, Pal D, Mitra AK. "Transporter targeted lipid prodrugs of cyclic cidofovir: A potential approach for the treatment of cytomegalovirus retinitis", J Pharm Sci. (Sept) 101(9):3249-3263, 2012.
40. Cholkar K, Patel A, Vadlapudi AD, Mitra AK., "Novel nanomicellar formulation approaches for anterior and posterior segment ocular drug delivery", Recent Patents on Nanomedicine, 2(2):82-95, 2012.
41. Patel SP, Mitra AK. "An overview of recent patents on nanocarrier based ophthalmic drug delivery systems", Recent Patents on Nanomedicine, 2(1):2-16, (15) 2012.
42. Jwala J, Vadlapatla RK, Vadlapudi AD, Boddu SHS, Pal D, Mitra AK. Differential Expression of Folate Receptor-Alpha, Sodium-Dependent Multivitamin Transporter, and Amino Acid Transporter (B ((0, +))) in Human Retinoblastoma (Y-79) and Retinal Pigment Epithelial (ARPE-19) Cell Lines, J Ocul Pharmacol Ther. (Jun) 28(3):237-44, 2012.
43. Vadlapudi AD, Vadlapatla RK, Mitra AK. Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery, Curr Drug Targets. (Jun) 13(7):994-1003, 2012.
44. Boddu SHS, Vaishya R, Jwala J, Vadlapudi A, Pal D, Mitra AK, et al., Preparation and Characterization of Folate Conjugated Nanoparticles of Doxorubicin using PLGA-PEG-FOL Polymer. Med Chem, 2:068-075, 2012
45. Vadlapudi AD, Patel A, Cholkar K, and Mitra AK, Recent Patents on Emerging Therapeutics for the Treatment of Glaucoma, Age Related Macular Degeneration and Uveitis, Recent Patents on Biomedical Engineering, 5(1):83-101, 2012.
46. Vadlapudi AD, Vadlapatla RK, Mitra AK. Current and Emerging Antivirals for the Treatment of Cytomegalovirus (CMV) Retinitis: an Update on Recent Patents. Recent Pat Antiinfect Drug Discov, 7(1):8-18, 2012.
47. Jin M; Earla R; Shah A; Earla RL; Gupte R; Mitra AK; Kumar A; Kumar S, A LC-MS/MS method for concurrent determination of nicotine metabolites and role of CYP2A6 in nicotine metabolism in U937 macrophages: Implications in oxidative stress in HIV + Smokers, J Neuroimmune Pharmacol, 7(1):289-99, 2012.
48. Vadlapatla RK; Vadlapudi AD; Kwatra D; Pal D; Mitra AK. Differential Effect of P-gp and MRP2 on Cellular Translocation of Gemifloxacin. Int J Pharm. 420(1):26-33, 2011.
49. Ponnaluri VKC, Vadlapatla RK, Vavilala DT, Pal D, Mitra AK, Mukherji M. Hypoxia induced expression of histone lysine demethylases: Implications in oxygen-dependent retinal neovascular diseases. Biochem Biophys Res Commun, 415(2):373-377, 2011.
50. Barot M, Gokulgandhi MR, Haghnegahdar M, Dalvi P, Mitra AK. Effect of Emergence of Fluoroquinolone Resistance on Intrinsic Expression of P-Glycoprotein Phenotype in Corneal Epithelial Cells. J Ocul Pharmacol Ther., 27(6):553-9, 2011.
51. Barot M; Gokulgandhi M; Mitra AK, Mitochrondrial Dysfunction in Retinal Diseases, Curr Eye Res, 36(12):1069-77, 2011.
52. Mishra GP, Bagui M, Tamboli V, Mitra AK, Recent applications of liposomes in ophthalmic drug delivery, J Drug Delivery, Vol. 2011, Article ID 863734, 1-14 pgs, 2011.
53. Gaudana R, Khurana V. Parenky A, Mitra AK., Encapsulation of Protein-Polysaccharide HIP Complex in Polymeric Nanoparticles, J Drug Deliv. Vol. 2011, Article ID 458128, 1-7 pgs, 2011.
54. Mishra GP, Tamboli V and Mitra AK, Effect of hydrophobic and hydrophilic additives on the sol-gel transition and release behavior of timolol maleate from polycaprolactone based hydrogel. Colloid Polym Sci. (Sep) 289(14):1553-1562, 2011.
55. Gaudana R, Parenky A, Vaishya R, Samanta SK, Mitra AK., Development and characterization of nanoparticulate formulation of a water soluble prodrug of dexamethasone by HIP complexation. J Microencapsul, 28(1):10-20, 2011.
56. Jwala J,. Boddu S.H.S, Paturi DK, Shah S, Smith SB, Pal D, Mitra AK, Functional Characterization of Folate Transport Proteins in Staten's Seruminstitut Rabbit Corneal Epithelial Cell Line, Curr Eye Res, 36(5):404-416, 2011.
57. Jwala J,. Boddu S.H.S, Shah S, Sirimulla S, Pal D, Mitra AK,, Ocular Sustained Release Nanoparticles Containing Stereoisomeric Di-Peptide Prodrugs of Acyclovir, J Ocul Pharmacol & Therapeu, 27(2):163-172, 2011.
58. Pal D, Kwatra D, Minocha M, Paturi DK, Budda B, Mitra AK.. Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals, Life Sci., 88:959-971, 2011.
59. Minocha M, Mandava NK, Kwatra D, Pal D, Folk WR, Earla R, Mitra AK., Effect of short term and chronic administration of Sutherlandia frutescens on pharmacokinetics of nevirapine in rats, Int J Pharm, 413(1-2):44-50, 2011.
60. Luo S, Wang Z, Patel M, Khurana V, Zhu X, Pal D, Mitra AK., Targeting SVCT for enhanced drug absorption: Synthesis and in vitro evaluation of a novel vitamin C conjugated prodrug of saquinavir, Int J Pharm, 414:77-85, 2011.
61. Tamboli V; Mishra GP; Mitra AK, Polymeric vectors for ocular gene delivery, Therapeutic Delivery (Future Science), 2(4):523-536, 2011.
62. Mishra GP, Tamboli V, Jwala J, Mitra AK, Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis, Recent Pat Inflamm Allergy Drug Discov, 5:26-36, 2011.
63. Katragadda S, Zhu X, Talluri SR, Mitra AK, Small Neutral Amino Acid Ester Prodrugs of Acyclovir Targeting Amino Acid Transporters on the Cornea: Possible Antiviral Agents Against Ocular HSV-1 Infections, Ophthalmology and Eye Diseases, 2:43-56, 2010.
64. Kumar S, Earla R, Jin M, Mitra AK, Kumar A, Effect of ethanol on spectral binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir. Biochem Biophys Res Commun. 402:163-167, 2010.
65. Boddu SHS; Jwala J; Chowdhury MR; Mitra AK, In vitro evaluation of a targeted and sustained release system for retinoblastoma cells using doxorubicin as a model drug, J Ocul Pharmacol & Therapeu, 26(5):459-468, 2010.
66. Talluri RS; Hariharan S; Karla PK; Mitra AK, Drug delivery to cornea and conjunctiva: Esterase- and protease-directed prodrug design, Encyclopedia of Eye, 2:42-53, 2010.
67. Kwatra D; Vadlapatla RK; Vadlapudi AD; Pal D; Mitra AK, Interaction of gatifloxacin with efflux transporters: A posible mechanism for drug resistance, Int J Pharmaceu 395(1-2):114-121, 2010.
68. Janoria KG; Boddu SHS; Natesan S; Mitra AK, Vitral pharmacokinetics of peptide-transporter-targeted prodrugs of ganciclovir in conscious animals, J. Ocul Pharmacol & Therapeu, 26(3):265-271, 2010.
69. Boddu S.H.S.; Gunda S; Earla R; Mitra AK, Ocular microdialysis: A continuous sampling technique to study pharmacokinetics and pharmacodynamics in the eye. Bioanalysis, 2(3):487-507, 2010.
70. Gaudana R; Ananthula HK; Parenky A; Mitra AK, Ocular Drug Delivery, The AAPS Journal, 12(3):348-360, 2010.
71. Luo S, Pal D, Shah SJ, Kwatra D, Paturi DK, Mitra AK; Effect of HEPES buffer on the uptake and transport of P-Glycoprotein substrates and large neutral amino acids, Mol. Pharm., 7(2):412-420, 2010
72. Velagaleti PR; Anglade E; Khan IJ; Gilger BC; Mitra AK. Topical delivery of hydrophobic drugs using a novel mixed nanomicellar technology to treat diseases of the anterior & posterior segments of the eye, Nanomicellar Technology, Drug Del Tech,10(4):42-47, 2010.
73. Missel P; Chastain J; Mitra A, Kompella U; Kansara V; Duvvuri S; Amrite A; Cheruvu N, In vitro transport and partitioning of AL-4940, Active metabolite of angiostatic agent anecortave acetate, in ocular tissues of the posterior segment. J. Ocular Pharmacol & Therap, 26(2):137-145, 2010.
74. Mandava N, Oberoi RK, Minocha M, Mitra AK; Transporter targeted drug delivery, J. Drug Del. Sci Tech., 20(2):89-99, 2010.
75. Earla R; Boddu S.H.S; Cholkar K; Hariharan S; Jwala J; Mitra AK, Development and validation of a fast and sensitive bioanalytical method for the quantitative determination of glucocorticoids - Quantitative measurement of dexamethasone in rabbit ocular matrices by liquid chromatography tandem mass spectrometry, J Pharm & Biomedical Analysis, 52:525-533, 2010.
76. Boddu S.H.S; Jwala J; Vaishya R; Earla R; Karla PK; Pal D; Mitra AK, Novel Nanoparticulate Gel Formulations of Steroids for the Treatment of Macular Edema, J Ocul Pharmacol Ther., 26(1):37:48, 2010.

BOOKS

Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, 2013 [IN PRESS].
Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 9781907568862 (250 pgs) 2013 [IN PRESS].
E-Book: Mitra AK. (editor), Advances in Ocular Drug Delivery, Research Signpost/Transworld Research Network (Publisher), Trivandrum, Kerala, India, 2012 (http://www.trnres.com/ebookcontents.php?id=121)
E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, (8 Chapters) Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].

BOOK CHAPTERS

1. Khurana V, Pal D, Minocha M, Mitra AK., "The Role of Transporters and Efflux Systems in Drug Delivery", Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, (Chapter 3) 2013 [IN PRESS].
2. Vadlapatla RK, Shah S, Vadlapudi AD, Mitra AK., "Prodrug and Bioconjugation", Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, (Chapter 6) 2013 [IN PRESS].
3. Gokulgandhi MR, Patel A, Cholkar K, Barot M, Mitra AK., "Nanoscale Drug Delivery Systems", Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, (Chapter 7) 2013 [IN PRESS].
4. Vadlapudi AD, Patel A, Vadlapatla RK, Paturi D, Mitra AK., "Implants", Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, (Chapter 9) 2013 [IN PRESS].
5. Barot M, Gokulgandhi MR, Ray A, Mitra AK., "Nanofiber", Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, (Chapter 11) 2013 [IN PRESS].
6. Patel M, Barot M, Renukuntla J, Mitra AK., "Protein/Peptide Drug Delivery", Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, (Chapter 13) 2013 [IN PRESS].
7. Khurana V, Kwatra D, Agrahari V, Mitra AK., "Recent Advances in Ocular Drug Delivery", Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, (Chapter 19) 2013 [IN PRESS].
8. Mandava N, Patel M, Mitra AK., "Advanced Drug Delivery to the Brain", Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, (Chapter 21) 2013 [IN PRESS].
9. Cholkar K, Dasari SR, Pal D, Mitra AK., "Eye: Anatomy, Physiology and Barriers to Drug Delivery", Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 9781907568862 (Chapter 1) 2013 [IN PRESS].
10. Pal D, Vadlapatla RK, Vadlapudi AD, Mitra AK., "Biology of Ocular Transporters and Receptors", Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 9781907568862 (Chapter 2) 2013 [IN PRESS].
11. Ray A, Cholkar K, Wang Z, Mitra AK., "Characterization of Ocular Transporters", Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 9781907568862 (Chapter 3) 2013 [IN PRESS].
12. Cholkar K, Ray A, Agrahari V, Pal D, Mitra AK., "Transporters and Receptors in the Anterior Segment of the Eye", Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 9781907568862 (Chapter 4) 2013 [IN PRESS].
13. Patel A, Gokulgandhi MR, Khurana V, Mitra AK., "Transporters and Receptors in the Posterior Segment of the Eye", Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 9781907568862 (Chapter 5) 2013 [IN PRESS].
14. Tamboli V, Shah S, Mitra AK., "Transporters in Drug Discovery and Delivery: A New Paradigm in Ocular Drug Design", Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 9781907568862 (Chapter 6) 2013 [IN PRESS].
15. Barot M, Patel M, Kwatra D, Mitra AK., "Transporter-Metabolism Interplay in the Eye", Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 9781907568862 (Chapter 7) 2013 [IN PRESS].
16. Boddu SHS, Menees AL, Ray A, Mitra AK, "A Brief Overview of Ocular Anatomy and Physiology", (Chap 1) E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].
17. Kwatra D, Vadlapatla RK, Khurana V, Pal D, Mitra AK, "Routes of Drug Delivery- Conventional vs. Novel Routes", (Chap 2 ) E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].
18. Renukuntla J, Shah S, Vadlapudi AD, Patel M, Mitra AK, "Drug Delivery to Anterior Segment of the Eye", (Chap 3) E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].
19. Gaudana RJ, Barot M, Patel A, Khurana V, Mitra AK, "Barriers for Posterior Segment Ocular Drug Delivery", (Chap 4) E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].
20. Tamboli V, Patel S, Mishra GP, Mitra AK, "Biodegradable Polymers for Ophthalmic Applications", (Chap 5) E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].
21. Karla PK, Boddu SHS, Patel A, Ako-Adouno AM, Mitra AK, "Novel Strategies to Enhance Ocular Bioavailability", (Chap 7) E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].
22. Rittenhouse KD, Atluri H, Boddu SHS, Mitra AK, "Microdialysis-Utility in Establishing PK/PD Relationships in Ophthalmology", (Chap 8) E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].
23. Yang X, Patel A, Vadlapudi AD, Mitra AK, "Application of Nanotechnology in Ocular Drug Delivery", (Chap 10) E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, 2013 [IN PRESS].
24. Patel M, Mandava N, Mitra AK. "Microdialysis in Ocular Drug Development", Muller, Markus (Ed.), Microdialysis in Drug Development, AAPS Advances in the Pharmaceutical Sciences, “Springer, New York, NY, Vol. 4, Pt 2, 197-222, 2013. [IN PRESS].
25. Tamboli V, Mishra GP, Mitra AK. "Biodegradable polymers for ocular drug delivery", in Mitra AK edits, E-Book: Advances in Ocular Drug Delivery, Research Singpost/Transworld Research Network (Publisher), Trivandrum, Kerala, India, Chapter 3, pp 65-86, 2012.
26. Paturi D; Patel M; Mitra R; Mitra AK, "Nasal and Pulmonary Delivery of Macromolecules to Treat Respiratory and Nonrespiratory Diseases", Pulmonary Nanomedicine: Diagnostics, Imaging, and Therapeutics, Neeraj Vij, Editor, Pan Stanford Publishing Pte. Ltd, Chapter 3, pp. 45-102, 2012.
27. Vadlapudi AD, Vadlapatla RK, Johnston TP, Mitra AK. "Peptides and proteins: Buccal absorption" in James Swarbrick Eds., Encyclopedia of Pharmaceuticals Sciences and Technology, 4th Edition, Informa Healthcare, Marcel Dekker, Inc. New York 2011.
28. Vaishya DR, Ananthula HK, and Mitra AK, "Microdialysis for Vitreal Pharmacokinetics" in Kompella UB and Edelhauser HF Eds. Drug Product Development for the Back of the Eye, Springer Science + Business Media, New York, USA, Chapter 2, Vol. 2, 21-45, 2011.
29. Karla PK; Boddu S.H.S.; Dasari C; Mitra AK. "Outward-Directed Transport", Adler's Physiology of the Eye (11th Edition), Publisher: (Saunders) Elsevier, New York, edited Leonard A. Levin, M.D, Siv F.E. Nilsson, Ph.D., James Ver Hoeve, MD, Samuel M. Wu, Ph.D., Chapter 17, 385-393, 2011.
30. Kwatra D; Vaishya R, Gaudana R, Jwala J; Mitra AK, "Ocular delivery using prodrugs", Prodrug and Targeted Delivery; Publisher Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, edited by Dr. Jarkko Rautio, Vol 47, Chapter 8, 181-205, 2010.
31. Talluri RS; Hariharan S; Karla PK; Mitra AK, "Drug Delivery to Cornea and Conjunctiva: Esterase- and Protease-Directed Prodrug Design," In: Darlene A. Dartt, editor, Encyclopedia of the Eye, Elsevier, Oxford: Academic Press; New York, NY, 2:42-53, 2010.
32. Mishra GP; Gaudana R; Tamboli VM; Mitra AK, "Recent Advances in Ocular Drug Delivery: Role of Transporters, Receptors, and Nanocarriers". Targeted Delivery of Small and Macromolecular Drugs, Publisher, Taylor & Francis Group, Boca Raton, Fl, edited by Ajit S. Narang & Dr Ram I. Mahato. Pages, 421-453 2010.