Mridul Mukherji, Ph.D.
Associate Professor with Tenure
UMKC School of Pharmacy
2464 Charlotte St.
Kansas City, MO 64108
Epigenetic mechanisms enforcing accessibility and usage of the genetic material are the foundation of cell differentiation and proliferation. Uncontrolled regulation of these processes leads to a number of diseases. Yet, molecular mechanisms governing these fundamental processes remain poorly understood. Recent studies have shown that the JmjC domain containing proteinsare iron(II), 2OG-dependent dioxygenases and can reverse histone methylation marks thus controlling gene expression.
We use our experience in the enzymology of iron(II), 2OG-dependent dioxygenases to understand the role of these enzymes during normal development and in disease states. Our long term goal is to develop cures for diseases caused by uncontrolled regulation of these enzymes by identifying small molecule inhibitors.