Hari K. Bhat, Ph.D.

Professor

UMKC School of Pharmacy
2464 Charlotte St.
HSB 5251
Kansas City, MO 64108

Phone: 816-235-5903
Email: bhath@umkc.edu

Bhat_Hari web

Biography:

Dr. Bhat received his B.Sc. in Biology and Chemistry, and M.Sc. in Organic Chemistry from University of Kashmir, Kashmir, India. He received his Ph.D. in Biochemistry from the University of Texas Medical Branch, Galveston, Texas.

Research Interests:

Dr. Bhat’s research interests focus on the elucidation of biochemical and molecular mechanisms of a) hormonal breast carcinogenesis; b) breast cancer chemoprevention using phytoestrogens; c) endocrine disruptors; and d) unequal burden of breast cancer among minority population. The mechanisms of hormonal breast carcinogenesis are being investigated using animal models, relevant cell lines and human tissue samples.

Representative Publications:

  1. Bhat, H.K. and Ansari, G.A.S. (1990) Cholesterol ester hydrolase mediated conjugation of haloethanols with fatty acids. Res. Toxicol., 3, 311-317.
  1. Bhat, H.K., Hacker, H.J., Bannasch, P., Thompson, E.A., and Liehr, J.G. (1993) Localization of estrogen receptors in interstitial cells of hamster kidney and in estradiol-induced renal tumors as evidence of the mesenchymal origin of this neoplasm. Cancer Res., 53, 5447-5451.
  1. Bhat, H.K., Han, X., Gladek, A., and Liehr, J.G. (1994)  Regulation of the formation of the major diethylstilbestrol-DNA adduct and some evidence of its structure.  Carcinogenesis, 15, 2137-2142.
  1. Bhat, H.K., Hiatt, William R., Hoppel, C.R., and Brass, E.P. (1999) Skeletal muscle mitochondrial DNA injury in patients with unilateral peripheral arterial disease. Circulation, 99, 807-812.
  1. Bhat, H.K. and Vadgama, J.V. (2000) Hamster estrogen receptor cDNA: cloning and mRNA expression. Steroid Biochem. Mol. Biol., 72, 47-53.
  1. Bhat, H.K., Calaf, G., Hei, T.K., Loya, T., and Vadgama, J.V. (2003) Critical role of oxidative stress in estrogen-induced carcinogenesis. Natl. Acad. Sci. USA, 100, 3913-3918 [PMCID: PMC153022].
  1. Patel, M.M. and Bhat, H.K. (2004) Differential oxidant potential of carcinogenic and weakly carcinogenic estrogens: Involvement of metabolic activation and P450. Biochem. Mol. Toxicol., 18, 37-42.
  1. Mense S.M., Hei, T.K., Ganju, R.K., and Bhat, H.K. (2008) Phytoestrogens and breast cancer prevention: Possible mechanisms of action. Health Perspect., 116, 426-433. [PMID: 18414622; PMCID: PMC2291001].
  1. Mense, S.M., Remotti, F., Bhan, A., Singh, B., El-Tamer, M., Hei, T.K., and Bhat, H.K. (2008) Estrogen-Induced Breast Cancer: Alterations in Breast Morphology and Oxidative Stress as a Function of Estrogen Exposure. Toxicol Appl. Pharmacol., 232, 78-85. [PMID: 18640140; PMCID: PMC2593408].
  1. Mense, S.M., Singh, B., Remotti, F., Liu, X., and Bhat, H.K. (2009) Vitamin C and α-Naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female ACI rats. Carcinogenesis, 30, 1202-1208. [PMID: 19406931; PMCID: PMC2704283].
  1. Singh, B., Bhat, N.K., and Bhat, H.K. (2011) Partial inhibition of estrogen-induced mammary carcinogenesis in rats by tamoxifen: Balance between oxidant stress and estrogen responsiveness. PloS One, 6, 225125. [PMID: 21966433; PMCID: PMC3180376].
  1. Singh, B., Bhat, N.K., and Bhat, H.K. (2012) Induction of NAD(P)H-Quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer. Carcinogenesis 33, 156-163. [PMID: 22072621; PMCID: PMC3276335]. 
  1. Singh, B. , and Bhat, H.K. (2012) Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer. Carcinogenesis 33, 2601-2610. [PMID:23027624; PMCID: PMC3510741].
  1. Singh, B., Ronghe, A.M., Chatterjee, A., Bhat, N.K., and Bhat, H.K. (2013) MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis. Carcinogenesis 34, 1165-1172. [PMID: 23492819; PMCID: PMC3643421].
  1. Singh, B., Shoulson R., Chatterjee, A., Ronghe, A., Bhat, N.K., Dim, D.C., and Bhat, H.K. (2014) Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways. Carcinogenesis 35, 1872-1880. [PMID:24894866; PMCID: PMC4123650].
  1. Ronghe, A., Chatterjee, A., Dandawate, P., Murphy, L., Padhye, S., and Bhat, H.K. (2016) 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, a novel resveratrol analog differentially regulates estrogen receptors α and β in breast cancer cells; Appl. Pharmacol., Jun 15; 301:1-13 [PMID: 26970359; PMCID:].
  1. Ronghe, A., Chatterjee, A., Bhat, N.K., Padhye, S., and Bhat, H.K. (2016) Tamoxifen synergizes with 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, in inhibiting the proliferation of breast cancer cells. Oncotarget, Jun 18, 2016 [PMID: 27364698]