Curriculum Vita

Professor Simon H. Friedman
 


EDUCATION

Postdoctoral Fellowship   1996-1999
California Institute of Technology (Peter Dervan)

Ph.D. Pharmaceutical Chemistry  1989-1996
University of California, San Francisco (George Kenyon)

 B.S. Chemistry  1984-1989
Massachusetts Institute of Technology (George Benedek/John Thomson)
  AWARDS AND HONORS
 
 
• NIH RO1 Synthetic and Analytical Methods Targeting Telomerase 2003-2008
• ACS-PRF Award Nucleic Acid Based Receptors Generated via Ligand Templated Polymerization 2002-2004
• UKC Faculty Scholar 2000-2001
• Science's Visions of the Future Essay Award 1999
• University of Missouri Research Board Award 1999-2000
• NIH Postdoctoral Fellowship (113 score, 0.6% percentile) 1996-1998
• B.F. Goodrich National Collegiate Inventors Prize  1994
• University of California Chancellor's Fellowship 1994-1995
• AFPE Josiah Kirby Lilly Memorial Fellowship 1993-1994
• American Chemical Society Medicinal Chemistry Fellowship  1991-1992
  PUBLICATIONS
 
 
Journal Articles
Friedman, S.H.; DeCamp, D.L.; Sijbesma, R.P.; Srdanov, G.; Wudl, F.; Kenyon, G.L. Inhibition Of the HIV-1 Protease By Fullerene Derivatives: Model Building Studies and Experimental Verification.
J. Am. Chem. Soc., 1993, 115: 6506-6509

Sijbesma, R.; Srdanov, G.; Wudl, F.; Castoro, J.A.; Friedman, S.H.; DeCamp, D.L.; Kenyon, G.L.
Synthesis of a Fullerene Derivative For the Inhibition of HIV Enzymes.
J. Am. Chem. Soc., 1993, 115: 6510-6512

Ganapathi, P.S.; Friedman, S.H.; Kenyon, G.L. ; Rubin, Y.
Sequential Double-Michael Additions Of Dienolates With C-60.
J. Org.Chem., 1995, 60: 2954-2955

Friedman, S.H.; Kenyon, G.L.
A Computational Strategy For the Design of Regiospecific Syntheses of Fullerene Derivatives.
J. Am. Chem. Soc., 1997, 119: 447-448

Friedman, S.H.; Ganapathi, P.S.; Rubin, Y.; Kenyon, G.L.
Optimizing the Binding of Fullerene Inhibitors of the HIV-1 Protease Through Predicted Increases in Hydrophobic Desolvation
J. Med. Chem. 1998, 41 (13) : 2424-2429

Francis, R; West, C.; Friedman, S.H.
Targeting Telomerase via its Key RNA/DNA Heteroduplex
Bioorganic Chemistry   2001, 29 (2):  107-117

West, C.; Francis, R.; Friedman, S.H.
Small Molecule/Nucleic Acid Affinity Chromatography:  Application for the Identification of Inhibitors of Telomerase Which Target Its Key RNA/DNA Duplex
Bioorganic and Medicinal Chemistry Letters 2001 11:  2727-2730

 Francis, R.; Friedman, S.H.
 A Rapid Direct Telomerase Assay Method Using 96-Well Streptavidin Plates
 Biotechniques  2002  32(5): 1154-1160
 
Francis, R; Friedman, S.H.
An Interference-Free Fluorescent Assay of Telomerase for the High-Throughput Analysis of Inhibitors
Analytical Biochemistry 2003, 323(1): 65-73

Shah, S.; Rangarajan, S.; Friedman, S.H.
Light Activated RNA Interference
Angewandte Chemie, Int. Ed. Eng.:   2005, 44: 1328-1332

  Book Chapters and Articles
  Friedman, S.H.
Buckyballs and HIV.
R and D Innovator, 1994, 3(5): 6-7

Friedman, S.H.; Wudl, F.; Rubin, Y.; Kenyon, G.L.
A Structure Based Approach to the Design of Fullerene Inhibitors of the HIV Protease; in Fullerenes. Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials ; Karl M. Kadish, Rodney S. Ruoff (eds.) Electrochemical Society, Pennington 1994, pp662-669

Friedman, S.H., Kenyon, G.L.
Bioorganic Chemistry,
Molecular Biology and Biotechnology, A Comprehensive Desk Reference; Meyers, R.A. (ed); VCH Publishers, Weinheim; 1995

Friedman,S.H., Kenyon, G.L.
Bioorganic Chemistry,
The Encyclopedia of Molecular Biology: Fundamentals and Applications ; Meyers, R.A. (ed); VCH Publishers, Weinheim; 1996

Friedman, S.H.; Karlsson, J.O.M.
A Novel Paradigm
Nature, 1997, 385: 480

Friedman, S.H.
Agents and IPOs, A Retrospective of My Academic Career
Science,  1999, 286:  1870-1872
 
 Friedman, S.H.
C60: A Highly Flexible Scaffold For Bioorganic Design
 The Exciting World of Nanocages and Nanotubes Electrochemical Society Proceedings: Fullerenes Volume 12: P. Kamat, D. Guldi, and K. Kadish (eds.)  Electrochemical Society 2002

Friedman, S.H.
Bioorganic Chemistry, Core Article
The Encyclopedia of Molecular Cell Biology and Molecular Medicine;  Meyers, R.A. (ed);
Wiley-VCH Publishers, Weinhim; 2003

 PATENTS Clark, J.I., Benedek, G.B., Siezen, R.J., Thomson, J.A., Friedman, S.H. "Chemical Prevention or Reversal of Cataract by Phase Separation Inhibitors"    U.S. Patents: #5,091,421 (1992); #5,290,813 (1994); European EP316438B1  (1993);
 European EP316438A1  (1989)
 

Friedman, S.H., Schinazi, R.F., Wudl, F., Hill,C.L., DeCamp, D.L., Sijbesma, R.P., Kenyon, G.L. "Water Soluble Fullerenes with Antiviral Activity"    US   #5,811,460  (1998)    US   #6,204,391  (2001)
 
 Friedman, S.H., Schinazi, R.F., Wudl, F., Hill,C.L., DeCamp, D.L., Sijbesma, R.P., Kenyon, G.L.  “Method of Treatment of Viral Infection Including HIV Using Water Soluble Fullerenes”
U.S. Patent:  U.S.  6,613,771  (2003)